Zosartan-K Tablets 1 Box 50mg

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Medicine

Detail Description

Losartan Potassium 50mg Tablets Specification

Requires Prescription: ✅ Yes

Generic Name

  • Losartan Potassium

Drug Class

  • Angiotensin II Receptor Blocker (ARB)

Dosage Form

  • Tablet

Description

Losartan is a selective AT1 receptor antagonist that blocks the action of angiotensin II, a potent vasoconstrictor.
Its action leads to vasodilation, reduced aldosterone secretion, increased renal excretion of sodium and water, and reduced blood pressure.
It does not interfere with bradykinin metabolism, differentiating it from ACE inhibitors.

It also helps reduce sympathetic tone, cardiac remodeling, and vascular hypertrophy.

Uses / Indications

🔹 Management of Hypertension
🔹 Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy
🔹 Treatment of diabetic nephropathy in patients with type 2 diabetes
🔹 Improves cardiovascular outcomes in heart failure patients
🔹 Prevention of kidney damage in hypertensive patients
🔹 Alternative for patients intolerant to ACE inhibitors

Dosage

Note: Always follow your doctor's prescribed dosage.

  • Adults (Hypertension/Nephropathy/Stroke Prevention):
    Initial: 50mg once daily
    May increase to 100mg daily (either once or divided doses)

  • Hepatic Impairment:
    Start with 25mg once daily

  • Pediatric (≥6 years):
    0.7 mg/kg once daily, not exceeding 100 mg/day

How to Use

  • Take the tablet orally, with or without food

  • Take it at the same time daily

  • Swallow whole with water

  • Do not double the dose if missed; take next dose as scheduled

Overdose

  • Symptoms may include severe hypotension, dizziness, or rapid heartbeat

  • Contact a doctor immediately in case of overdose

When Not to Use

  • During pregnancy (especially 2nd and 3rd trimester)

  • If allergic to Losartan or any component

  • In bilateral renal artery stenosis or volume depletion

Side Effects

🟡 Common:

  • Dizziness

  • Headache

  • Fatigue

  • Nasal congestion

  • Back pain

🔴 Serious but rare:

  • Hyperkalemia

  • Hypotension

  • Edema

  • Renal impairment

  • Angioedema

Precautions & Warnings

⚠️ Use cautiously in:

  • Patients with renal impairment or hepatic dysfunction

  • Elderly patients due to risk of hypotension

  • Patients on potassium supplements or potassium-sparing diuretics

🟨 First-dose hypotension may occur—monitor BP carefully
🟧 Avoid use in pregnancy—risk of fetal toxicity

Drug Interactions

❌ May interact with:

  • Potassium supplements or diuretics (↑ risk of hyperkalemia)

  • NSAIDs (↓ renal function and antihypertensive effect)

  • Lithium (↑ risk of lithium toxicity)

  • Barbiturates / Antipsychotics (enhance hypotensive effect)

Food Interactions

  • Can be taken with or without food

  • Avoid high potassium foods/supplements

  • Alcohol may increase the risk of dizziness or fainting

Storage / Disposal

✅ Store at room temperature (20–25°C)
❌ Keep away from moisture, light, and heat
🛑 Keep out of reach of children and pets

Pregnancy Category

  • Category D (Risk to fetus—contraindicated in pregnancy)