Zestoretic 28 Tablets

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Detail Description

Zestoretic 20mg Tablet Specification

Requires Prescription: ✅ Yes

Generic Name(s)

  • Lisinopril (ACE Inhibitor)

  • Hydrochlorothiazide (Thiazide Diuretic)

Drug Class

  • Combination of Antihypertensive (ACE inhibitor) + Diuretic

Used For

  • Treatment of high blood pressure (hypertension)

  • Prevention of stroke, heart attack, and kidney problems

  • Improves blood circulation and reduces fluid retention

How It Works

🔹 Lisinopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II, a substance that narrows blood vessels. This causes blood vessels to relax, lowering blood pressure.

🔹 Hydrochlorothiazide increases the excretion of sodium and water by the kidneys, reducing blood volume and pressure. It also helps to prevent fluid buildup in the body.

Dosage

  • Typically taken once daily, with or without food

  • Dosage should be based on doctor’s recommendation

  • Available in various strengths; Zestoretic 20mg usually refers to Lisinopril 20mg + Hydrochlorothiazide 12.5mg

How to Use

  • Take at the same time each day

  • Drink a full glass of water

  • Do not stop medication without doctor consultation

Side Effects

🟡 Common Side Effects:

  • Dizziness, headache, fatigue

  • Dry cough (due to Lisinopril)

  • Increased urination

🔴 Serious Side Effects (Rare):

  • Angioedema (swelling of face, lips, or throat)

  • Difficulty breathing

  • Electrolyte imbalance (high potassium)

  • Severe hypotension

  • Kidney dysfunction

When Not to Use

❌ Do not use if:

  • Allergic to ACE inhibitors or thiazide diuretics

  • History of angioedema

  • Severe kidney impairment or anuria (no urine output)

  • Pregnancy (especially 2nd & 3rd trimester)

Precautions & Warnings

⚠️

  • Pregnancy/Breastfeeding: Not recommended; may harm the fetus

  • Kidney or liver disease: Monitor closely

  • Avoid potassium supplements and salt substitutes containing potassium

  • Monitor blood pressure, electrolytes, and renal function regularly

Drug Interactions

May interact with:

  • NSAIDs (↓ antihypertensive effect, kidney damage risk)

  • Potassium supplements or diuretics (↑ risk of hyperkalemia or dehydration)

  • Lithium (toxicity risk ↑)

  • Alcohol (enhanced blood pressure-lowering effect)

Food Interactions

  • Avoid high-potassium foods (e.g., bananas, oranges, salt substitutes)

  • Limit alcohol intake

Pregnancy Category

  • D (2nd and 3rd trimester) – Can cause injury or death to the fetus

  • Always consult your doctor before use

Storage

✅ Store at room temperature (15–30°C)
❌ Protect from moisture, heat, and light
🔒 Keep out of reach of children