Calfina Plus Tablets 37.5mg/325mg Specification

Product Form: Tablets
Pack Size: 1 Box = 1 Strip (1 Strip = 10 Tablets)
Requires Prescription: Yes

Generics

• Tramadol HCl

• Paracetamol

Used For

• Moderate to severe pain

• Pain & inflammation relief

How it works

• Tramadol: A non-selective agonist of the µ, δ, and κ opioid receptors (with higher affinity for µ receptors). Its analgesic effect is also mediated by inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. It additionally has an antitussive effect.

• Paracetamol: Produces central analgesic effects via activation of descending serotonergic pathways. Its mechanism may involve inhibition of prostaglandin synthesis or an active metabolite influencing cannabinoid receptors.

Usage and Safety

Dosage: As prescribed by a doctor (contains Tramadol HCl + Paracetamol).

Side Effects

• Very common (≥1 in 10): Nausea, dizziness, drowsiness.

• Common (≤1 in 10): Vomiting, constipation, flatulence, diarrhea, stomach pain, dry mouth, itching, sweating, headache, shaking, confusion, sleep disorders, anxiety, nervousness, mood changes.

• Uncommon (≤1 in 100): Increased pulse/blood pressure, arrhythmias, tingling/numbness, tinnitus, muscle twitching, depression, nightmares, hallucinations, memory lapses, difficulty breathing, difficulty swallowing, blood in stools.

Drug Interactions

• Carbamazepine

• Buprenorphine, Nalbuphine, Pentazocine (opioid analgesics)

• Triptans

• SSRIs

• Morphine, Codeine (incl. cough medicines)

• Baclofen

• Benzodiazepines

• Certain antidepressants

• Warfarin, Phenprocoumon (blood thinners)

• Metoclopramide, Domperidone, Ondansetron

• Cholestyramine

Indication

Indicated for the treatment of moderate to severe pain.

When Not to Use

Do not use if:

• Allergic to tramadol, paracetamol, or excipients.

• You have acute alcohol poisoning.

• Taking sleeping pills, pain relievers, or mood-altering drugs.

• You are taking or have taken MAOIs (monoamine oxidase inhibitors) within the last 14 days (used for depression/Parkinson’s).

Precautions

• Opioids must only be used by the patient they are prescribed for.

• Do not share your medicine with others.

• Avoid higher/frequent dosing due to risk of addiction, overdose, and death.

Warnings

1. Use with caution if you have epilepsy, seizures, or history of head injury, shock, or severe headache with vomiting.

2. Long-term use may cause addiction. Follow doctor’s instructions carefully regarding duration and tapering.

3. Use with caution in liver disease. Yellowing of skin/eyes (jaundice) may indicate liver damage.

Additional Information

• Pregnancy Category: Consult physician before use.

Storage

Yes – Store at room temperature, away from direct light and heat.