Byvas Tablets 5Mg (1 Box = 2 Strips = 14 Tablets) Specification

Requires Prescription:
Yes

Generics

Nebivolol HCl

Used For

• Hypertension

• Stable, mild, and moderate chronic heart failure (in elderly patients ≥70 years)

• May be used alone or in combination with other antihypertensive agents

How it works

Nebivolol is a ß1-selective adrenoceptor antagonist with unique vasodilating properties:

• Vasodilation occurs via the L-arginine/nitric oxide pathway, unlike classical beta-blockers.

• Lacks intrinsic sympathomimetic and membrane-stabilizing activity at therapeutic concentrations.

• Does not block α1-adrenergic receptors at clinically relevant doses.

Usage and Safety

Dosage:
As prescribed by a physician (contains Nebivolol HCl).

Side Effects

• Common: Headache, dizziness, paresthesia, dyspnea, constipation, nausea, diarrhea, tiredness, edema.

• Uncommon: Nightmares, depression, impaired vision, bradycardia, heart failure, AV block, hypotension, intermittent claudication, bronchospasm, dyspepsia, flatulence, vomiting, pruritus, rash, erythema, impotence.

• Rare: Syncope, aggravated psoriasis.

Drug Interactions

• Calcium channel blockers (Verapamil, Diltiazem)

• Antiarrhythmics (Disopyramide)

• Digitalis glycosides

• Other β-blockers

• Reserpine, Guanethidine, Clonidine

• CYP2D6 inhibitors (Quinidine, Propafenone, Fluoxetine, Paroxetine)

• Cimetidine

• Sildenafil

Indication

• Treatment of essential hypertension

• Treatment of stable, mild to moderate chronic heart failure in elderly patients (≥70 years) as part of standard therapy

When not to Use (Contraindications)

Avoid use in patients with:

• Hypersensitivity to Nebivolol or formulation components

• Severe hepatic insufficiency

• Acute heart failure, cardiogenic shock, or decompensated heart failure needing IV inotropes

• Sick sinus syndrome (including sino-atrial block)

• Second or third degree heart block (without pacemaker)

• History of bronchospasm or asthma

• Untreated pheochromocytoma

• Metabolic acidosis

• Bradycardia (HR < 60 bpm)

• Hypotension (SBP < 90 mmHg)

• Severe peripheral circulatory disturbances

Precautions

• Administer cautiously in patients with compensated congestive heart failure.

• Discontinue if heart failure worsens.

Warnings

1. Diabetes & Hyperthyroidism: May mask signs of hypoglycemia or hyperthyroidism (e.g., tachycardia).

2. Abrupt Withdrawal: Do not discontinue suddenly—taper gradually (halve dose weekly). Abrupt stop may worsen angina or heart failure.

3. Peripheral Vascular Disease: May worsen arterial insufficiency; use with caution.

Pregnancy Category

Consult physician before use.

Storage

Yes – Store at room temperature, away from direct light and heat.