Byscard Tablets 10Mg (1 Box = 1 Strip = 14 Tablets) Specification

Requires Prescription:
Yes

Generics

Nebivolol HCl

Used For

• Hypertension

• Stable, mild, and moderate chronic heart failure (in elderly patients ≥70 years)

• May be used alone or in combination with other antihypertensive agents

How it works

Nebivolol is a ß1-selective adrenoceptor antagonist with vasodilating properties.

• Its vasodilating action is attributed to interaction with the L-arginine/nitric oxide pathway, which is unique compared to other beta-blockers.

• It lacks intrinsic sympathomimetic and membrane-stabilizing activity at therapeutic doses.

• At clinically relevant doses, nebivolol does not block α1-adrenergic receptors.

Usage and Safety

Dosage:
As directed by a physician (contains Nebivolol HCl).

Side Effects

• Common: Headache, dizziness, paresthesia, dyspnea, constipation, nausea, diarrhea, tiredness, edema.

• Uncommon: Nightmares, depression, impaired vision, bradycardia, heart failure, AV block, hypotension, intermittent claudication, bronchospasm, dyspepsia, flatulence, vomiting, pruritus, rash, erythema, impotence.

• Rare: Syncope, aggravated psoriasis.

Drug Interactions

• Calcium channel blockers (Verapamil, Diltiazem)

• Antiarrhythmic agents (Disopyramide)

• Digitalis glycosides

• Other β-blockers

• Reserpine, Guanethidine, Clonidine

• CYP2D6 inhibitors (Quinidine, Propafenone, Fluoxetine, Paroxetine)

• Cimetidine

• Sildenafil

Contraindications (When not to Use)

Do not use in patients with:

• Hypersensitivity to Nebivolol or any excipients

• Severe hepatic insufficiency

• Acute heart failure, cardiogenic shock, or decompensated heart failure requiring IV therapy

• Sick sinus syndrome (including sino-atrial block)

• Second or third degree heart block (without pacemaker)

• History of bronchospasm or bronchial asthma

• Untreated pheochromocytoma

• Metabolic acidosis

• Bradycardia (HR < 60 bpm)

• Hypotension (systolic BP < 90 mmHg)

• Severe peripheral circulatory disturbances

Precautions

• Use cautiously in patients with compensated congestive heart failure.

• If heart failure worsens, consider discontinuation.

Warnings

1. Diabetes & Hyperthyroidism: May mask symptoms of hypoglycemia or hyperthyroidism (e.g., tachycardia).

2. Abrupt Withdrawal: Avoid sudden discontinuation—taper dose gradually (halve weekly). Sudden stop may worsen angina or heart failure.

3. Peripheral Vascular Disease: May aggravate symptoms of arterial insufficiency; use with caution.

Pregnancy Category

Consult physician before use.

Storage

Yes – Store at room temperature, away from direct light and heat.