Bynevol Tablets 2.5mg (1 Box = 1 Strip = 14 Tablets)

Requires Prescription (YES/NO)

✅ Yes

Generics

• Nebivolol Hydrochloride (Nebivolol HCl)

Used For

• Hypertension (High Blood Pressure)

• Stable, mild to moderate chronic heart failure (in elderly patients ≥70 years, as add-on therapy)

How it Works

Nebivolol is a ß1-selective adrenoceptor antagonist (beta-blocker) with unique properties:

• Provides vasodilation via the L-arginine/nitric oxide pathway, unlike traditional beta-blockers.

• Reduces heart rate and cardiac workload.

• Lacks intrinsic sympathomimetic or membrane-stabilizing activity at therapeutic concentrations.

• Does not block alpha1-adrenergic receptors at clinical doses.

Usage and Safety

Dosage: As directed by physician (Nebivolol HCl, typically once daily).

Side Effects

Common:

• Headache, dizziness, paresthesia

• Dyspnea, constipation, nausea, diarrhea

• Tiredness, edema

Uncommon:

• Nightmares, depression, impaired vision

• Bradycardia, heart failure, AV-block, hypotension

• Bronchospasm, intermittent claudication

• Dyspepsia, flatulence, vomiting, rash, pruritus

• Impotence

Rare:

• Syncope, worsening psoriasis

Drug Interactions

• Calcium channel blockers (verapamil, diltiazem)

• Antiarrhythmic agents (disopyramide)

• Digitalis glycosides

• Other ß-blockers, reserpine, guanethidine

• Clonidine

• CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine)

• Cimetidine

• Sildenafil

Indications

• Treatment of essential hypertension

• Treatment of stable, mild to moderate chronic heart failure (elderly ≥70 years, with standard therapies)

• Can be used alone or with other antihypertensive agents

When Not to Use

Contraindicated in patients with:

• Hypersensitivity to Nebivolol or excipients

• Severe hepatic insufficiency

• Acute heart failure, cardiogenic shock, or heart failure decompensation needing IV inotropes

• Sick sinus syndrome, SA block

• 2nd or 3rd degree heart block (without pacemaker)

• History of bronchospasm / asthma

• Untreated phaeochromocytoma

• Metabolic acidosis

• Bradycardia (<60 bpm before therapy)

• Hypotension (SBP <90 mmHg)

• Severe peripheral circulatory disorders

Precautions

• Use cautiously in compensated congestive heart failure; discontinue if condition worsens.

Warnings

Warning 1:

• May mask hypoglycemia symptoms in diabetics.

• May mask tachycardia in hyperthyroidism.

• Avoid abrupt withdrawal to prevent rebound symptoms.

Warning 2:

• Discontinue gradually (halve dose weekly).

• If angina worsens or acute coronary insufficiency develops, reinstitute therapy promptly.

Warning 3:

• May aggravate arterial insufficiency in peripheral vascular disease patients.

Additional Information

Pregnancy Category: Consult physician before use.

Storage

✅ Store at room temperature, away from direct light and heat.