Bayer Gravibinan Injection Ampoule 1 Piece x 1ml

Gravibinan IM Injection 5mg/2ml

Requires Prescription: Yes

Generics:

• Hydroxyprogesterone caproate

• Estradiol valerate

Used For:
Hormone replacement therapy; treatment of endangered pregnancy.

How it Works:

• Hydroxyprogesterone caproate: A long-acting progestational steroid ester that transforms proliferative endometrium into secretory endometrium, promotes mammary gland duct development, and inhibits gonadotropic hormone production/release.

• Estradiol valerate: Replaces estrogen hormones lost during menopause, relieving symptoms such as hot flashes and vaginal dryness.

Dosage:
As prescribed by the physician.

Side Effects:

• Breast cancer

• Endometrial hyperplasia or cancer

• Ovarian cancer

• Venous thromboembolism (blood clots in legs or lungs)

• Heart disease

• Stroke

• Neuro-ocular lesions

• Melasma

• Cystitis

• Breast tenderness

Drug Interactions:
Consult physician or pharmacist for potential interactions.

When Not to Use:

• Excessive thickening of womb lining

• Breast cancer

• Thrombosis

• Liver disease

• Allergic reactions to ingredients

Precautions:

• Progestins may decrease glucose tolerance—monitor blood glucose in diabetic patients.

Warnings:

1. Progestational drugs may cause fluid retention; monitor patients with asthma, migraine, epilepsy, cardiac or renal dysfunction.

2. Discontinue immediately if symptoms of blood clots appear (e.g., leg swelling/redness, chest pain, breathing difficulty).

3. Discontinue if jaundice occurs.

Pregnancy Category:
Consult physician before use.

Storage:
Store at room temperature, away from direct light and heat.