Ascard Plus 81mg/75mg 10 Tablets

Ascard Plus Specification

Requires Prescription:
Yes

Generics

• Aspirin

• Clopidogrel

Used For

• Stroke prevention

• Cardiovascular event prevention

How It Works

• Clopidogrel inhibits platelet activation and aggregation by irreversibly binding to the P2Y12 class of ADP receptors on platelets.

• Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) by binding its acetyl group to a serine residue, preventing the conversion of arachidonic acid to thromboxane A2 (TXA2), a potent inducer of platelet aggregation.

Ascard Plus Usage and Safety

Dosage

• As prescribed (contains fixed-dose combination of Aspirin and Clopidogrel)

Side Effects

• Uncommon: Thrombocytopenia, leucopenia, eosinophilia

• Rare: Neutropenia (including severe cases)

• Very Rare:

  • Thrombotic thrombocytopenic purpura (TTP)

  • Aplastic anaemia

  • Pancytopenia

  • Agranulocytosis

  • Severe thrombocytopenia

  • Acquired haemophilia A

  • Granulocytopenia

  • Anaemia

Drug Interactions

• With Both Components: Oral anticoagulants, heparin, thrombolytics, NSAIDs, SSRIs

• Clopidogrel-specific:

  • Inducers/Inhibitors of CYP2C19

  • Proton Pump Inhibitors (PPIs)

  • Anti-retroviral therapies (ART)

• Aspirin-specific:

  • Uricosurics (e.g., benzbromarone, probenecid, sulfinpyrazone)

  • Methotrexate

  • Tenofovir

  • Valproic acid

  • Alcohol

Indication

• Prevention of ischemic events, myocardial infarction, stroke, and cardiovascular death in patients with Acute Coronary Syndrome (ACS)

When Not to Use

• Hypersensitivity to clopidogrel, aspirin, or any excipients

• Severe hepatic impairment

• Active pathological bleeding, such as:

  • Peptic ulcer

  • Intracranial hemorrhage

Ascard Plus Precautions

• Due to bleeding and haematological risks, monitor blood cell counts and conduct appropriate testing if bleeding symptoms appear during therapy.

Ascard Plus Warnings

Warning 1

• Monitor for bleeding, including occult bleeding, especially in the first weeks of treatment or after cardiac procedures/surgery.

• Avoid use with oral anticoagulants unless absolutely necessary.

Warning 2

• Acquired haemophilia may develop with clopidogrel. If aPTT is prolonged (with or without bleeding), suspect acquired haemophilia.

• Discontinue clopidogrel and refer to a specialist.

Warning 3

• In patients with recent transient ischaemic attack or stroke, combination therapy (aspirin + clopidogrel) increases major bleeding risk.

• Use with caution unless proven beneficial in a clinical setting.

Additional Information

Pregnancy Category

• Always consult your physician before use.

Storage

• Store at room temperature, away from direct light and heat.