Artem DS Plus 40 / 240mg 8 Tablets

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Medicine

Detail Description

Artem-DS Plus Specification

Requires Prescription

Yes

Generics

  • Artemether

  • Lumefantrine

Drug Class

  • Artemisinin Derivative + Antimalarial (Aryl Alcohol)

Used For

  • Treatment of malaria

How It Works

Artemether and Lumefantrine act on different sites within the malarial parasite.

  • Artemether contains an endoperoxide bridge, which produces free radicals toxic to Plasmodium parasites.

  • Lumefantrine disrupts the conversion of heme to hemozoin, leading to parasite death.

This dual mechanism increases effectiveness against acute malaria infections.

Indication

Used for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including resistant strains.

Dosage

Contains Artemether and Lumefantrine.
Dosage depends on age, weight, and clinical condition.
Take with food or milk to enhance absorption.
Follow the dosing schedule provided by your doctor.

Side Effects

Very Common:
Palpitations, headache, dizziness, abdominal pain, anorexia, vomiting, nausea, joint and muscle pain (arthralgia, myalgia), fatigue, sleep disturbances.

Common:
Amnesia, tingling sensations (paresthesia), diarrhea, skin rash or itching, cough, QT prolongation on ECG, insomnia, balance or gait problems.

Uncommon:
Increased liver function tests, clonus, reduced sensation (hypoesthesia), coordination issues (ataxia), drowsiness.

Drug Interactions

Avoid with:

  • CYP3A4 inhibitors (e.g., erythromycin, ketoconazole, itraconazole, cimetidine, HIV protease inhibitors)

  • CYP2D6 inhibitors (e.g., flecainide, metoprolol, imipramine, amitriptyline, clomipramine)

  • Mefloquine (may reduce effectiveness or increase risk of side effects)

When Not to Use

Contraindicated in patients with known hypersensitivity to Artemether, Lumefantrine, or any of the ingredients in the formulation.

Precautions

Due to limited safety data, avoid using Artemether + Lumefantrine with other antimalarial agents unless no alternatives exist.
Use caution in patients with renal, hepatic, or cardiac conditions.
Ensure ECG monitoring and correction of any electrolyte imbalances.
Monitor patients who have reduced food intake during treatment, as this may affect absorption and treatment success.

Warnings

  • Use with caution in severe kidney, liver, or heart conditions. ECG monitoring may be necessary.

  • Exercise caution when combined with other drugs metabolized by CYP3A4.

  • Inadequate food intake may lead to poor absorption and increased risk of relapse (recrudescence).

Pregnancy Category

Always consult your physician before using this medication during pregnancy or breastfeeding.

Storage

Store at room temperature, away from direct light, heat, and moisture.
Keep in original packaging and out of reach of children.