Adfolic Od Tablets 10 600mg

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Detail Description

💊 Adfolic OD – Specification Sheet

📦 Requires Prescription:

No

🔬 Generic Name:

Quatrefolic (Active form: 5-Methyltetrahydrofolate)

🧪 Drug Class:

Folic Acid Supplement

✅ Uses / Indications

Adfolic OD is used in the following conditions:

  • Pregnancy & lactation to prevent neural tube defects

  • Folate deficiency (including that caused by epilepsy medications)

  • Prevention of spontaneous abortions

  • Hyperhomocysteinemia

  • Chronic kidney dialysis or long-term RBC damage

  • Cognitive disorders like dementia, depression, and Alzheimer’s disease

  • Dietary supplementation for adults and elderly

  • Patients with increased folate requirement or poor folic acid absorption

⚙️ How It Works

Quatrefolic (5-MTHF) is the active form of folic acid, bypassing conversion steps required by folic acid. It:

  • Participates in nucleotide synthesis (DNA/RNA building)

  • Converts homocysteine to methionine with Vitamin B12

  • Supports amino acid metabolism

  • Reduces risk of hyperhomocysteinemia, a factor in cardiovascular and neurological diseases

💊 Dosage

  • Contains Quatrefolic

  • Dose to be determined by physician based on deficiency level or condition

🚫 When Not to Use

Avoid Adfolic OD in:

  • Untreated Vitamin B12 deficiency (e.g. pernicious anemia)

  • Known hypersensitivity to folate or Quatrefolic

  • Long-term use in elderly without cobalamin absorption testing

  • Malignant disease, unless folate deficiency is a complication

  • Addisonian or macrocytic anemia unless B12 is supplemented

⚠️ Side Effects

🧠 Nervous System:

  • Headache, dizziness, agitation, seizures

  • Confusion, hallucinations, psychosis

  • Drowsiness or coma (rare and dose-dependent)

🧴 Skin / Immune Reactions:

  • Rash, urticaria, erythema, pruritus

  • Stevens-Johnson syndrome, anaphylaxis, toxic epidermal necrolysis

⚠️ Others:

  • GI symptoms: Nausea, flatulence, anorexia, abdominal distension

  • Peripheral edema, fever

💊 Drug Interactions

May reduce effectiveness of:

  • Fosphenytoin, Phenytoin, Phenobarbital, Primidone (↑ seizure risk)

  • Pyrimethamine (↓ antiparasitic efficacy)

  • Methotrexate (↓ anticancer or immunosuppressive effect)

May be reduced by:

  • Sulfasalazine (↓ folic acid absorption)

⚠️ Precautions & Warnings

⚠️ Precaution:

  • B12 deficiency must be corrected before folate use

  • Uncorrected B12 deficiency may lead to neurological damage

  • Monitor vegetarians, infants, or patients with megaloblastic anemia

⚠️ Warnings:

  1. Folate-dependent tumors may worsen with folic acid

  2. High doses may worsen seizures in epilepsy patients

  3. Not for general supplementation in healthy pregnant women (lower doses advised)

👶 Pregnancy Category

  • Consult your doctor before use during pregnancy or breastfeeding

🧴 Storage Instructions

  • Store at room temperature

  • Keep away from direct light, heat, and moisture

  • Do not refrigerate or expose to extreme temperatures