Pyodine Solution Specification

Requires Prescription (YES/NO)

Yes

Generics

Glycopyrrolate USP

Used For

Anti-Muscaranic

How it works

The following pharmacological effects are observed: Pyrolate (Glycopyrrolate Injection USP) inhibits the muscarinic actions of acetyl choline. Depending on the dose, Pyrolate (Glycopyrrolate Injection USP) may reduce the motility and secretory activity of the gastrointestinal system, the tone of the ureter and urinary bladder. It also has a slight relaxant action on the bile duct and gallbladder. In general, smaller doses of anti-cholinergics inhibit salivary and bronchial secretions, sweating and can cause dilatation of the pupil and increase in heart rate. Large doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit the gastric acid secretion. Anti-spasmodic effect on gastrointestinal tract is due to the direct action on smooth muscle .

Pyodine Solution Usage And Safety

Dosage

Glycopyrrolate USP

Side Effects

Anti-cholinergics produce certain side effects most of which are extension of their pharmacological actions; they include: dry mouth, urinary retention, blurred vision, tachycardia, decreased sweating, loss of taste, headache, drowsiness, weakness, nausea, vomiting, suppression of lactation, constipation, allergic reactions and some degree of mental confusion or excitement.

Drug Interactions

Amantadine , cyclopropane , anticholinergic agents , levodopa .

Indication

INDICATIONS: a) Anti-Muscarinic l Pyrolate (Glycopyrrolate Injection USP) is indicated for use as a pre-operative, anti-muscarinic drug to reduce salivary, tracheo-bronchial, and pharyngeal secretions. l To reduce the volume of free gastric acid and to raise pH of gastric contents above 2.5. l It also blocks cardiac vagal inhibitory reflexes during induction and intubation. b) Anti -Arrhythmic Pyrolate (Glycopyrrolate Injection USP) may be used intra-operatively to counteract drug induced or vagal traction reflexes with associated arrhythmias. c) Reversal of Neuromuscular Blockade Pyrolate (Glycopyrrolate Injection USP) is indicated to reverse the neuromuscular block produced by non-depolarizing neuromuscular blocking agents, in combination with Neo-choline (Neostigmine) and pyridostigmine.

When not to Use

Known hypersensitivity to glycopyrrolate . Due to its benzyl alcohol content, Pyrolate should not be used in newborn or children less than 1 month of age. . Concurrent glaucoma. . Obstructive diseases of the gastrointestinal tract (as in achalasia, pyloroduodenal stenosis) . Paralytic ileus, intestinal atony. Un-stable cardiovascular status in acute haemorrhage. Severe ulcerative colitis. Myasthenia gravis.