Clobetasol propionate is a highly active corticosteroid with topical anti-inflammatory activity. The major effect of clobetasol propionate on skin is a non-specific anti-inflammatory response, partially due to vasoconstriction and decrease in collagen synthesis.The use of nystatin in the local treatment of candidal infections of the skin and of neomycin as a broad-spectrum antibiotic is well known.The principle action of the preparation is based on the anti-inflammatory activity of the corticosteroid. The broad spectrum antibacterial and anti-candidal activity provided by the combination of neomycin and nystatin allow this effect to be utilized in the treatment of condition which are or are likely to become infected.