Generics

• Ampicillin
• Cloxacillin

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Used For

Bacterial Infections

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How It Works

Both ampicillin and cloxacillin are bactericidal antibiotics that act by interfering with the formation of the bacterial cell wall in dividing organisms, leading to bacterial death.

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Ampiclox Neonatal Usage and Safety

Dosage

• Contains Ampicillin and Cloxacillin. Dosage should be prescribed by a physician based on the patient's condition and age.

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Side Effects

Patients may experience the following side effects:

• Hematological: Hemolytic anemia, leucopenia, thrombocytopenia, agranulocytosis.
• Allergic Reactions: Anaphylaxis, skin rash, urticaria, pruritus, bullous reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), exfoliative dermatitis, and purpura.
• Neurological: Myoclonus, convulsions.
• Gastrointestinal: Diarrhea, nausea, vomiting, pseudomembranous colitis.
• Hepatic: Hepatitis, cholestatic jaundice.

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Drug Interactions

This medicine may interact with:

• Probenecid.
• Oral contraceptives.
• Sulphonamides and acetylsalicylic acid.
• Bacteriostatic drugs.
• Allopurinol.

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Indications

This medication is indicated for treating infections caused by mixed Gram-positive (excluding methicillin-resistant Staphylococcus aureus [MRSA] and methicillin-resistant coagulase-negative Staphylococcus [MRCoNS]) and Gram-negative bacteria.

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When Not to Use

This medication is contraindicated:

• In patients with a history of hypersensitivity to beta-lactam antibiotics (e.g., penicillins, cephalosporins) or excipients.
• For ocular administration.

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Ampiclox Neonatal Precautions

• Avoid usage if infectious mononucleosis or acute/chronic leukemia of lymphoid origin is suspected, as the occurrence of a skin rash is associated with these conditions after administration of ampicillin.

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Ampiclox Neonatal Warnings

1. Penicillin Hypersensitivity: Caution is advised when administering neonatal oral drops to babies whose mothers are hypersensitive to penicillin.
2. Previous Hypersensitivity: Before initiating therapy, inquire about any history of hypersensitivity to beta-lactams.
3. Allergic Reactions: If an allergic reaction occurs, discontinue the medication and institute an appropriate alternative therapy. Treat adverse reactions symptomatically.

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Additional Information

Pregnancy Category

Always consult your physician before using this medication during pregnancy.

Storage

Store this medicine at room temperature, away from direct light and heat.