Generic: Hypoglycaemic (Excluding Insulin)

Drug Name: Glimepiride

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Introduction

Glimepiride is a medication used to treat type 2 diabetes mellitus, in combination with an appropriate diet and exercise regimen. It is prescribed when blood sugar levels are inadequately controlled by metformin alone or in combination with other antidiabetic medicines. It does not treat type 1 diabetes or diabetic ketoacidosis. Consistent use helps maintain normal blood sugar levels, prevent organ damage, and lower the risk of heart, kidney, and brain diseases.

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How to Use

• Take this medicine by mouth with a glass of water.
• Administer right before breakfast or a main meal.
• Swallow it whole—do not crush or chew.
• Take it at the same time every day to help you remember.
• Follow your doctor’s instructions precisely.

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Expert Advice

Avoid this medication if:

• You are allergic to this medicine or its components (e.g., sulfa).

Consult your doctor if:

• You are pregnant, planning to conceive, or breastfeeding.
• You have digestive problems.
• You have a medical history of:
  • Liver or kidney disease.
  • Thyroid issues.
  • Blood disorders.
• You are taking other medications, particularly NSAIDs, thyroid medications, or blood pressure medicines (e.g., beta-blockers or ACE inhibitors).

Be careful about:

• Eating meals on time to maintain blood sugar levels.
• Taking the medicine as prescribed, ideally with food.
• Following lifestyle changes recommended by your physician.
• Avoiding alcohol consumption.

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Primary Uses

Type II Diabetes

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Indications

This medication is used to manage non-insulin-dependent diabetes.

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Side Effects

Patients may experience:

• Low blood sugar levels (hypoglycemia).
• Temporary visual impairment.
• Stomach disturbances.
• Liver impairment.
• Metallic taste.
• Rash.
• Abnormal Vitamin B12 levels.

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Warnings

Pregnancy

• This medicine is not recommended for pregnant women due to potential adverse effects on the unborn child. Consult your doctor for guidance.

Lactation

• Not recommended for nursing mothers. Consult your doctor before use.

Driving

• May cause dizziness. Avoid driving immediately after taking this medicine.

Liver

• Use with caution in liver disease. Dose adjustment may be necessary.

Kidney

• Use with caution in kidney disease. Dose adjustment may be necessary.

Alcohol

• Avoid alcohol consumption as it may exacerbate side effects.

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Precautions

• Inform your doctor about your complete medical history, especially if you have heart, liver, kidney disease, or diabetes.
• Do not discontinue the medication without consulting your doctor.
• Notify your doctor about all current medications and any upcoming surgeries.

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Contraindications

This medicine is contraindicated in patients with:

• Allergy to sulfonylureas or sulfonamides.
• Type I diabetes.
• Diabetic ketoacidosis.
• Metabolic acidosis.
• Lactic acidosis.
• Malnutrition or debilitation.
• Adrenal insufficiency.
• Severe lung dysfunction.
• Hypoxemia (low oxygen levels in blood).
• Dehydration.
• Congestive heart failure.

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FAQs

What family of drugs does this medicine belong to?

This medicine belongs to the sulfonylurea class, used for managing diabetes.

Can this drug be used with other antidiabetic medications?

Yes, but only if recommended by your physician. Extra caution is necessary to avoid low blood sugar.

Can this drug be used with insulin?

Yes, if your doctor prescribes it alongside insulin. Follow dosing instructions carefully.

Can this drug cause low blood sugar?

Yes, it is a potential side effect. Regular meals can help prevent it.

Can I take this drug during pregnancy?

No, it is not recommended during pregnancy. Consult your doctor.

Can I use this drug while breastfeeding?

No, it is not advised. Consult your doctor for alternatives.

Is it safe for kidney or liver disease?

Use with caution; consult your doctor for dose adjustments.

What happens if I skip a dose?

Take it as soon as you remember, but skip if it’s almost time for your next dose. Do not double the dose.

Can this drug cause weight changes?

It may cause slight weight loss but not weight gain.

Can it cause vitamin deficiencies?

Prolonged use may result in Vitamin B12 deficiency, leading to anemia.

How should I store this medicine?

Store in a cool, dry place, away from light and moisture.

What is lactic acidosis, and does this drug cause it?

Lactic acidosis is a rare, potentially fatal condition caused by lactic acid buildup. It may occur with overdoses. Seek immediate medical help if you notice symptoms like stomach pain, dizziness, breathing difficulty, or muscle aches.